3053 - Coordination compound with selective activity against Klebsiella pneumonae and Pseudomonas aeruginosa

Istrati  Dorin., Gulea  Aurelian., Tsapcov Victor, Zariciuc Elena, Cotovaya Aliona.

 

New nickel coordination compound  of hydrazinecarbothioamide derivative with high activity towards Klebsiella pneumoniae and Pseudomonas aeruginosa  has been obtained using the directed synthesis method. The new compound displays selective high bactericide and bacteriostatic activity that exceeds by 30 times the half maximal inhibitory concentration (IC50) of prototype.

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