Milutin Milosavljević, Aleksandar Marinković, Jelena Rusmirović, Slobodan Petrović
Chemical Industry „Župa“ a.d.; Faculty of Technology and Metallurgy, University of Belgrade
The new technologies for treatment of waste water from production of tetramethylthiuram monosulfide (TMTS), containing ammonium isothiocyanate, for production of N-alkyl(aryl)- and N,N-dialkylsubstituted thioureas was developed. TMTS was produced in the form of suspension by reacting of cyanide, generated in reaction of potassium cyanide and ammonium chloride, with tetramethylthiuram disulfide (TMTD). After filtration of TMTS obtained filtrate, waste water containing by-product ammonium isothiocyanate, was further treated with appropriate amount of alkyl(aryl)- or dialkyl amine in presence of hydrochloric acid. Product was extracted with ethyl acetate, and recrystallized from methanol giving pure N-alkyl(aryl)- and N,N-dialkyl substituted thioureas – METHOD I. Tretment of isocynatae with benzoyl chloride, aprropriate amount of alkyl(aryl)- or dialkyl amine and sodium hydroxide produce also N-alkyl(aryl)- and N,N-dialkyl substituted thioureas - METHOD II. After recrystallization from methanol high purity and somewhat lower yields and of thioureas was obtained in comparison to METHOD I. THE PRESENTED NEW TECHNOLOGIES FOR PRODUCTION OF THIOUREAS DERIVATIES WAS PROTECTED BY SUBMITTED PATENT APPLICATION OF SERBIA.